Scientists hail cure for most common cause of blindness
Published: October 6, 2006
A drug that could save thousands of people from going blind is being hailed as a “miraculous” advance against a modern epidemic. But the drug, Lucentis, has sparked a row over its cost after ophthalmologists found that it worked in a similar way to an existing drug that was equally safe and effective and sells at a fraction of the price.
An estimated 27,000 people in England and Wales develop wet macular degeneration, the commonest cause of blindness, each year. The progressive condition slowly destroys the retina, causing the loss of central vision.
Until recently there has been no treatment for macular degeneration, which affects one in three people by the age of 75 and is increasing as the population ages. The first breakthrough came with the development of photo dynamic therapy, which helps 7,000 of the 27,000 sufferers a year, and a drug, Macugen, launched last year has been shown to halve the risk of severe loss of vision.
Results from two trials of Lucentis, conducted in the United States, show it is even more effective, actually improving vision in a third of patients and halting the deterioration in most of the rest.
In an editorial headlined “A very effective treatment for neovascular macular degeneration”, The New England Journal of Medicine, which publishes the findings today, says the drug is “miraculous” and the results “exciting”.
But it uses identical terms to describe the rival drug, Avastin, normally used to treat cancer and not licensed for macular degeneration, and says a “head to head comparison of the two drugs is now warranted”.
Such a trial would cost tens of millions of dollars and Genentech, the Californian biotech company that makes both drugs, is reluctant to fund it because it could undermine its profits.
Lucentis costs around £1,000 a dose and is given by injection directly into the eye. Patients need injections monthly for up to two years and possibly for life. It is licensed in the US and a licence is expected in the UK by the end of the year.
Avastin, licensed as a treatment for colon cancer two years ago, costs from £10 to £25 a dose when given by injection into the eye. Its use in macular degeneration was discovered by a US consultant ophthalmologist, Philip Rosenfield, chief author of the new study of Lucentis, who noticed that the two drugs worked in a similar way. He experimented on two patients and after he published his results last year, ophthalmologists around the world rapidly took up the treatment, using the drug “off licence”, with the consent of patients.
Professor Rosenfield described Avastin as “truly a wonder drug” and said it showed both how good drug companies were “and, on the flip side, how greedy they are”. He called for governments to fund clinical trials in the public interest.
Steve Winyard, policy director of the Royal National Institute for the Blind, said Lucentis was “very good news” for patients and a “significant further step forward”. Trials to test Lucentis against Avastin were now necessary and should be funded by the Government.
“It could be a very good spend-to-save measure [to run a government-funded trial]. If the drug companies don’t want to do it maybe the NHS should.”
Winfried Amoaku, consultant ophthalmologist at Queen’s Medical Centre in Nottingham and deputy chairman of the scientific committee of the Royal College of Ophthalmologists said: “[Lucentis] is expensive but you can’t put a price on vision. If you lose your sight you lose your independence and the care you need ends up costing more.”
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