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Physical Activity Improves Survival Rate From Breast Cancer

Published: August 31, 2005

The news as of late has been overwhelming that not only is regular exercise a great prescription for the prevention of disease, but the evidence points to regular exercise’s ability to increase the survival rate of certain diseases.

In the most recent issue of JAMA, women with breast cancer who engaged in a moderate but consistent amount of physical activity had a better survival rate than those who don’t exercise.

Reduced Levels Of Circulating Ovarian Hormones

There is reason for the higher survival rate is the link between physical activity and lower levels of circulating ovarian hormones. Lower estrogen levels among physically active women with breast cancer could potentially improve survival, although few data exist to support this hypothesis.

Michelle D. Holmes, M.D., Dr.P.H., of Brigham and Women’s Hospital and Harvard Medical School, Boston, and colleagues conducted a study to examine whether higher levels of physical activity after a breast cancer diagnosis would be associated with longer survival.

Physical Activity Measured in MET-hours per Week

The study was based on responses from 2,987 female registered nurses in the Nurses’ Health Study who were diagnosed with stage I, II, or III breast cancer between 1984 and 1998 and who were followed up until death or June 2002, whichever came first. Physical activity was measured as metabolic equivalent task ( MET ) hours. Three MET-hours is equivalent to walking at average pace of 2 to 2.9 mph for 1 hour.

Moderate amount appears to be optimal. The reduction rate peaks at 9-14.9 MET-hours per week.

The benefit of physical activity was particularly apparent among women with hormone-responsive tumors. The risk of breast cancer death was 50 % lower for women with hormone-responsive tumors who engaged in 9 or more MET-hours per week of activity compared with those who do less.

“… Women with breast cancer who follow the Centers for Disease Control and Prevention recommendations for all individuals in the United States to exercise at moderate intensity for 30 or more minutes per day for 5 or more days per week may survive longer,” the authors conclude.

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Published in Cancer and Science & Technology
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